what is xiaflex used for

What Is Xiaflex Used For?

This medication is used to treat certain conditions (Dupuytren’s contracture, Peyronie’s disease) that are caused by a certain protein (collagen) in your body. Collagen is a tough and strong substance and is found in the knots/cords of the hand in Dupuytren’s contracture or plaques in the penis in Peyronie’s disease.

What is the success rate of Xiaflex?

Xiaflex Success Rates

Success rates vary but studies demonstrate an average 34% improvement in the curvature (or 17-degree decrease from baseline curvature). 60% of men getting Xiaflex experienced improvement compared to 30% with placebo.

How much do Xiaflex injections cost?

Xiaflex costs $3,300 an injection, so a full course of eight injections would cost about $26,000, in addition to a doctor’s fee. Doctors already use less expensive drugs off-label to treat Peyronies, including injections of a generic blood pressure drug.

How long does it take Xiaflex to work?

Treatment cycles are typically spaced about 4-6 weeks apart. Some men may see improvements after one or two cycles, while men with severe curvatures may benefit more from three or four cycles.

How painful is Xiaflex?

Pain. Although Xiaflex is not uncomfortable to receive, some patients have significant pain for up to 48 hours after the injection, with rare patients having discomfort beyond this period. Verapamil is more painful to receive, likely due to the volume of fluid, but is not significantly painful thereafter.

How long does XIAFLEX last?

Your doctor will check your hand, try to straighten the finger if needed, and apply a splint. Wear the splint every night at bedtime as long as directed by your doctor (for up to 4 months).

Why was XIAFLEX discontinued?


This is the result of a business decision made by Actelion Pharmaceuticals Pty Ltd, a Janssen Pharmaceutical Company of Johnson & Johnson, and not the result of safety or efficacy considerations of XIAFLEX®.

Can Peyronie’s disease go away by itself?

Peyronie’s disease rarely goes away on its own. In most men with Peyronie’s disease, the condition will remain as is or worsen. Early treatment soon after developing the condition may keep it from getting worse or even improve symptoms.

Is Xiaflex covered by medical?

The XIAFLEX Copay Assistance Program can cover up to $1200 of your out-of-pocket costs for each injection of XIAFLEX (collagenase clostridium histolyticum). How much you pay for XIAFLEX depends on your health benefits or insurance coverage. To find out if you qualify, call 1-800-743-2382.

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Is Xiaflex covered under insurance?

Most insurance companies cover the cost of treatment with Xiaflex for Peyronie’s disease as long as the curvature is greater than 30 degrees. Medicare covers Xiaflex for men with Peyronie’s disease.

How often is Xiaflex given?

Xiaflex is usually given in a treatment cycle of 1 to 3 injections given 4 weeks apart. After your injection, do not touch or put pressure on the treated area of the hand for the rest of the day. Keep the treated hand elevated until bedtime.

Does stretching really help peyronies?

Yes, certain types of exercise can help Peyronie’s disease. According to Massachusetts General Hospital, gentle stretching of the sheath can correct the curvature by breaking down some of the scar tissue.

What is the latest treatment for Peyronie’s disease?

Eur J Rheumatol Inflamm.

Is Xiaflex safe for Peyronie’s?

XIAFLEX ® (collagenase clostridium histolyticum) is the only nonsurgical treatment option for appropriate adult men with Peyronie’s disease approved by the Food and Drug Administration (FDA).

Do Peyronie’s injections work?

Studies have shown 34% improvement in penile curvature in men who underwent treatment with Xiaflex injection compared to 18% improvement in men treated with saline injection. In a study of 832 men, three men had penile fracture.

what is xiaflex used for
what is xiaflex used for

How long does it take to fix Peyronie’s disease?

Peyronie disease often happens in a mild form that heals on its own in 6 to 15 months. There is no cure for Peyronie disease. A wide variety of medicines may be tried. Most are taken by mouth, but some are injected into the plaque.

What type of drug is XIAFLEX?

Xiaflex is a prescription medicine used to treat the symptoms of Dupuytren Contracture and Peyronie Disease. Xiaflex may be used alone or with other medications. Xiaflex belongs to a class of drugs called Dermatologics, Other; Urologics, Other; Rheumatologics, Other.

How safe is xiaflex?

XIAFLEX can cause serious side effects, including: Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection.

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What is Dupuytren’s contracture surgery?

During Dupuytren’s contracture surgery, the surgeon makes a cut (incision) in your hand and takes out the thickened tissue. This can improve the mobility of your fingers. Some people have contractures return. They may need surgery again.

Is Xiaflex approved in Canada?

Xiaflex® is the first, non-surgical treatment approved by Health Canada for Dupuytren’s Contracture. It presents itself as a less invasive treatment option for adult patients with this disease.

How do you break up Peyronie’s scar tissue?

Your doctor might suggest injecting a drug into the penis to break up the scar tissue. Some doctors use a drug called verapamil. Studies show it can decrease the curve and pain in many men. Collagenase clostridium histolyticum (Xiaflex) is another injected drug for treating Peyronie’s.

Can you take Viagra if you have Peyronie’s disease?

Can you take Viagra if you have Peyronie’s disease? In a word, yes. Phosphodiesterease inhibitors like Viagra (sildenafil) have been studied both alone and in conjunction with other therapies to treat erectile dysfunction and penile curvature from Peyronie’s disease.

How do you break up Peyronie’s plaque?

Collagenase link. Intralesional collagenase injections (Xiaflex) are currently the only FDA-approved treatment for Peyronie’s disease. Collagenase is an enzyme that helps break down the substances that make up plaques. Breaking down the plaques reduces penile curving and improves erectile function.

How much does Peyronie’s treatment cost?

The mean annual, per-individual cost of Peyronie’s disease treatment increased from $1,531 in 2007 to $10,339 in 2018. The cost increase was greatest for injectable therapies, which rose from $811 per individual in 2007 to $16,184 in 2018, a 19-fold increase.

Is there a generic for xiaflex?

Xiaflex (collagenase Clostridium histolyticum) is a nonsurgical enzyme treatment derived from Clostridium histolyticum bacteria for adults with Dupuytren’s contracture when a cord can be felt. Xiaflex is available in a generic form as collagenase Clostridium histolyticum.

Will Medicare pay for Peyronie’s disease?

For patients who require surgical treatment, Medicare pays for surgical treatment of Peyronie’s disease including penile prosthesis, penile plication. Medicare Advantage including Medicare HMO plans also cover treatment for Peyronie’s disease.

How do I order Xiaflex?

To learn more, or if you have questions, call Endo Advantage at 1-877-XIAFLEX (1-877-942-3539) Monday through Friday, from 9:00 AM to 8:00 PM ET.

Does Xiaflex work for Dupuytren’s contracture?

XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture when a cord can be felt. Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections.

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What is a collagenase injection?

Collagenase Clostridium histolyticum injection (Xiaflex) is used to treat Dupuytren’s contracture (a painless thickening and tightening of tissue [cord] beneath the skin in the palm of the hand, which may make it difficult to straighten one or more fingers) when a cord of tissue can be felt upon examination.

How much vitamin E should I take for Peyronie’s?

Vitamin E is commonly used to treat Peyronie’s disease. In 1948, Scott and Scardino31 reported a beneficial effect in 23 men treated with a dosage of 200 mg/d to 300 mg/d.

What happens if Peyronie’s disease is left untreated?

If left untreated, Peyronie’s disease may cause fibrotic, nonexpansile thickening of relatively discrete areas of the corpora tunica, typically resulting in focal bend, pain or other functional or structural abnormalities of the erect penis. Many cases resolve without treatment.

Does xiaflex increase size?

Xiaflex with first generation PTT devices also had not impact on length. When patients used RestoreX along with the injection treatment, they experienced a nearly 2cm gain in length or about 17%.

Can surgery fix Peyronie’s disease?

Surgery has been shown to be the most effective treatment for Peyronie’s disease in correcting the curvature of the penis. However, it is usually only recommended in severe cases for patients who fail to respond to non-surgical therapy and have curvature for longer than 12 months.

Is Peyronie’s disease permanent?

Peyronie’s disease is usually a permanent condition. True Peyronie’s disease rarely goes away on its own, but can occasionally change even years after diagnosis in response to further injuries. The changes in the penis can always be improved using a variety of treatments.

Xiaflex for Peyronie’s Disease

Melting Away Peyronies Disease? What You Need to Know About Xiaflex Treatment

Collagenase injections (Xiaflex) for Peyronie’s disease | UroChannel

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