Chytridiomycosis is an infectious disease of amphibians caused by the fungus Batrachochytrium dendrobatidis (Bd). It was first discovered in 1993 in Australia after a massive mortality event involving several species of frog.
Safe and effective treatments for chytridiomycosis are urgently needed to control chytrid fungal infections and stabilize populations of endangered amphibian species in captivity and in the wild. Currently, the most widely used anti-Bd treatment is itraconazole.
Chytridiomycosis is an infectious disease that affects amphibians worldwide. It is caused by the chytrid fungus (Batrachochytrium dendrobatidis), a fungus capable of causing sporadic deaths in some amphibian populations and 100 per cent mortality in others.
In the late 1990s, researchers discovered that frogs in both Australia and Panama were infected with a deadly fungus, which they named Batrachochytrium dendrobatidis — Bd, for short. The fungus turned up in other countries, but studies of its DNA suggest that Bd originated on the Korean Peninsula.
Transmission of Infection and Disinfection
Bd is transmitted by a motile flagellated zoospore that is susceptible to drying (dessication) and heat.
Chytrid fungus is probably transferred by direct contact between frogs and tadpoles, or through exposure to infected water. The disease may not kill frogs immediately, and they can swim or hop to other areas before they die, spreading fungal spores to new ponds and streams.
Chytridiomycosis is present on every continent except for Antarctica, though the disease is having the biggest impact in South and Central America, Australia, and North America. In the United States, chytrid disease has been confirmed in 46 out of the 50 states.
Symptoms of infection in adult amphibians include reddening of the skin, excessive shedding of skin, skin ulceration (especially at the tips of the toes), abnormal posture, apparent “seizures” or unusual behaviours such as nocturnal species being active during the day.
Simply stepping in an infected puddle and walking around can contribute to spreading the fungus. Though the impacts are on a global scale, each of us can have an important part in preventing the further spread of chytrid fungus. Clean your shoes after walking through muddy puddles.
Bd has been found on all continents where amphibians occur; in other words, every continent except Antarctica (Fisher et al. 2009). Bd has also been linked with serious declines almost everywhere that amphibians occur (North, Central, and South America, Australia, Africa, and Europe; Van Sluys and Hero 2010).
In the past 50 years, more than 500 amphibian species have experienced population declines worldwide, and 90 of them have gone extinct, due to a deadly fungal disease called chytridiomycosis (or chytrid fungus), which corrodes frog flesh.
Bd is the only chytrid fungus known to feed on living vertebrates. It primarily affects the skin of amphibians, causing the disease known as amphibian chytridiomycosis. Amphibians breathe and take up water through their skin. Chytridiomycosis interferes with these essential processes.
Some amphibians can tolerate Bd, but in many others, it degrades the animals‘ permeable skin, which they use to breathe and regulate their water levels. Runaway infections trigger a death spiral that ends in cardiac arrest.
The immune system of amphibians is very similar to that of all other vertebrate groups. The cells, the organs, and the critical effector molecules (antibodies, complement, cytokines and chemokines) are very similar to those found in fish, reptiles, birds and mammals.
Chytrid fungus infects only amphibians because of their thin, sensitive skin. Humans, other mammals, reptiles, birds, fish, and invertebrates are not affected.
Chytridiomycosis: an infectious disease in amphibians, caused by the aquatic chytrid fungus Batrachochytrium dendrobatidis (Bd). With chytridiomycosis, the infected skin becomes very thick. This is deadly to amphibians because amphibians absorb water and electrolytes through their skin.
The global emergence and spread of the pathogenic, virulent, and highly transmissible fungus Batrachochytrium dendrobatidis, resulting in the disease chytridiomycosis, has caused the decline or extinction of up to about 200 species of frogs.
Populations of some susceptible frog species have recovered and have begun to re-colonize upland sites from which they were extirpated during initial outbreaks of chytridiomycosis [10].
Like all amphibians, frogs need moisture to survive. Instead of drinking water, frogs absorb water through their skin. Though many species are found in watery environments such as ponds and wetlands, many adult frogs live in woodlands or grassy areas and return to ponds only to breed each year.
In the United States, histoplasmosis commonly occurs in the Mississippi and Ohio River valleys, though it can occur in other areas, too. It also occurs in Africa, Asia, Australia, and in parts of Central and South America.
Vinegar can keep frogs away by causing a burning sensation at their feet. This is a more humane way of discouraging frogs from infesting your home. For maximum effect, mix the vinegar with an equal amount of water and then apply it with a spray bottle in the area with frogs. Avoid spraying vinegar on plants.
Because amphibians drink through their skin, the resulting disease (called chytridiomycosis) disrupts their hydration and electrolyte balance, killing them. … They found Bd caused declines in 500 amphibian species, 90 of which are now extinct in the wild. Another 124 have lost more than 90 percent of their population.
Batrachochytrium dendrobatidis, the fungus that causes chytridiomycosis, or chytrid, and has devastated amphibian populations throughout the world, came from Asian amphibians, according to a study published in the journal Science. The Oriental fire-bellied toad (Bombina orientalis) hails from Korea and China.
The chytrid fungus invades the surface layer of the frog’s skin, causing damage to the keratin layer. Infected frogs begin to die roughly 21 days post-infection, and though larvae stages (eggs or tadpoles) are susceptible to infection, deaths are generally restricted to the adult life stage.
Frogs can be eaten by birds like herons, crows, and ducks; reptiles like lizards, snakes, and alligators; big game fish like bass and muskellunge; small mammals like skunks foxes, raccoons, otters, and monkeys, and water bugs, other frogs, and humans.
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